The objective of the present study was to develop an effective formulation for Ibuprofen chewable tablets with an emphasis on organoleptic properties. The methods involve coating the drug substance itself, granulating the drug and then coating these granules using substances like ethyl cellulose, hydroxy propyl methyl cellulose, Eudragit E 100, Eudragit RD 100 and granulating the drug along with Excipients like mannitol and sorbitol. To optimize the formulation, effect of various Excipients (diluents and vehicles alone & in combination), sweetening and flavoring agents on physicochemical & organoleptic properties of tablets were studied. Stability studies were carried out for finalized formulation in suitable packing like blister and strip and then keeping at different temperatures & humidity conditions for 60 days. Evaluation studies of the optimized formulation before and after stability studies showed no significant difference in drug content, drug release profiles, physicochemical and organoleptic properties indicated that an efficient taste masking formulation was developed for Ibuprofen chewable tablets.
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